摘要 |
A drug delivery system which includes a plurality of microcapsules, each microcapsule containing a plasminogen activator entrapped in a biocompatible, biodegradable, substantially water-soluble polymeric matrix such that the plasminogen activator is releasable therefrom upon exposure of the microcapsules to an aqueous environment, as well as methods for preparing same. Methods of treating a thrombotic condition and reducing the time required for reperfusion of an occluded blood vessel are also described, which include parenterally administering to a mammal a therapeutically effective amount of a pharmaceutical composition which includes a plurality of such microcapsules.
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