| 摘要 |
<p>The present invention relates to a method for determining abnormal development of cloned embryos. The method provides for the detection and/or measurement of aberrant epigenetic reprogramming in cloned mammalian embryos. Aberrant reprogramming may lead to abnormality in cloned embryos. According to a first aspect of the invention there is provided a method for detecting and/or measuring aberrant epigenetic reprogramming in a cloned mammalian embryo, which includes the step of determining the methylation state of said embryo. According to a second aspect of the invention there is provided a method of diagnosis of aberrant epigenetic reprogramming in a cloned mammalian embryo, which includes the step of determining the methylation state of said embryo. Furthermore, the invention provides a method of diagnosis of the propensity of a cloned mammalian embryo for abnormal development, which method includes the step of determining the methylation state of said embryo.</p> |
