发明名称 INDOLE DERIVATIVES AS MCP1 RECEPTOR ANTAGONISTS.
摘要 <p>A compound of formula (I) wherein: R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is a halo group or a trifluoromethyl group; R4 is a halo group or a trifluoromethyl group; R5 is hydrogen or halo; R6 is hydrogen or halo; provided that when R5 and R6 are both hydrogen, and one of R3 or R4 is chloro or fluoro, then the other is not chloro or fluoro; or a pharmaceutically acceptable salt or prodrug thereof. These compounds have useful activity for the treatment of inflammatory disease, specifically in antagonising an MCP1 mediated effect in a warmblooded animal such as a human being.</p>
申请公布号 MXPA02006611(A) 申请公布日期 2002.09.30
申请号 MX2002PA06611 申请日期 2001.01.11
申请人 ASTRAZENECA AB 发明人 KETTLE, JASON, GRANT
分类号 A61K31/404;A61P29/00;A61P43/00;C07D209/42 主分类号 A61K31/404
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