CELL-TRANSDUCIBLE CATALASE FUSION PROTEIN AND THE USE THEREOF

摘要

PURPOSE: Provided are a cell-transducible catalase fusion protein and its use, thereby directly transducing human catalase into a cell in protein level and scavenging harmful reactive oxygen species in the cell. CONSTITUTION: The catalase fusion protein is manufactured by covalent bond of a protein tranducing domain(PTD) to a catalase, wherein the protein transducing domain is characterized by one selected from oligo arginine consisting of HIV-1 Tat(49-57), Tat(51-57), Tat(50-56), Tat(50-57), Tat(50-55) and 5-12 arginine residues, and oligopeptide consisting of 5-12 arginine or lysine residues. It has amino acid sequence of SEQ ID NO:4, 6 or 8.