METHODS AND COMPOSITIONS FOR MODIFYING A RECEPTOR TYROSINE KINASE/PROTEIN TYROSINE KINASE SIGNAL TO AN APOPTOTIC SIGNAL IN A CELL

摘要

Methods and compositions for modifying a RTK/PTK signal in a cell to an apoptotic signal in the cell. Methods and compositions for activating an apoptotic signal in a cell are described involving linking a RTK/PTK signaling pathway that transduces a RTK/PTK signal in the cell to an apoptotic signaling pathway that transduces an apoptotic signal in the cell thereby increasing the apoptotic signal in the cell. A RTK/PTK signaling pathway in a cell may be linked to an apoptotic signaling pathway in the cell by creating a new signaling pathway in the cell comprising signaling molecules of an RTK/PTK signaling pathway that transduce a RTK/PTK signal, and signaling molecules of the apoptotic signaling pathway that promote apoptosis. A RTK/PTK signaling pathway in a cell can be linked to an apoptotic signaling pathway in the cell using a domain of a signaling molecule that regulates the RTK/PTK signal and a domain of a signaling molecule that promotes apoptosis. Applications for the methods and compositions are described.