发明名称 |
METHODS OF AND COMPOUNDS FOR INHIBITING CALPAINS |
摘要 |
A method is disclosed for inhibiting calpain by contacting calpain with one or more HIV protease inhibitors or analogs. Included are embodiments for identifying subjects at risk of suffering calpain-mediated physiological damage and administering to them the HIV protease inhibitors or analogs. Alternatively, a compound may be administered to a subject following an actual event implicating activation of calpain. Also included are methods of treating or preventing calpain-mediated physiological damage in a subject by administering to the subject a therapeutically effective amount of a pharmaceutical composition which includes at least one HIV protease inhibitor or analog. The pharmaceutical compositions can be used in the treatment of a variety of conditions or diseases implicated by or associated with calpain activation, including cardiovascular diseases.
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申请公布号 |
US2002115665(A1) |
申请公布日期 |
2002.08.22 |
申请号 |
US20010847872 |
申请日期 |
2001.05.02 |
申请人 |
THE GOVERNMENT OF THE USA, AS REPRESENTED BY TH SECRETARY, DEPARTMENT |
发明人 |
DEPETRILLO PAOLO B.;WAN WENSHUAI |
分类号 |
A61K31/27;A61K31/341;A61K31/427;A61K31/472;A61K31/4725;A61K31/496;A61K45/06;A61P7/02;A61P19/02;A61P25/00;A61P25/28;(IPC1-7):A61K31/537;A61K31/705;A61K31/47 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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