发明名称 |
LIGANDS OF INTEGRIN RECEPTORS |
摘要 |
The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the alpha vss3 integrin receptor. The invention also relates to the novel compounds, to the use thereof and to pharmaceutical preparations which contain said compounds. Examples of said compounds include benzazepines, benzodiazepines and thieno[3,2-b]azepines, used for treating arteriosclerosis, rheumatoid arthritis, restenosis after vessel damage or stent implantation, angioplasty, acute kidney failure, microangiopathy associated with angiogenesis, diabetic angiopathy, thrombocyte-mediated vascular occlusion, arterial thrombosis, congestive heart-failure, myocardial infarct, apoplexy, cancer, osteoporosis, hypertension, psoriasis or viral, parasitic or bacterial diseases, inflammation, wound healing, hyperparathyroidism, Paget's bone disease, malignant hypercalcemia, or metastatic osteolytic lesions. |
申请公布号 |
WO0193840(A3) |
申请公布日期 |
2002.08.08 |
申请号 |
WO2001EP06397 |
申请日期 |
2001.06.06 |
申请人 |
BASF AG;GENESTE, HERVE;KLING, ANDREAS;LANGE, UDO;SEITZ, WERNER;GRAEF, CLAUDIA, ISABELLA;SUBKOWSKI, THOMAS;HORNBERGER, WILFRIED;LAUTERBACH, ARNULF |
发明人 |
GENESTE, HERVE;KLING, ANDREAS;LANGE, UDO;SEITZ, WERNER;GRAEF, CLAUDIA, ISABELLA;SUBKOWSKI, THOMAS;HORNBERGER, WILFRIED;LAUTERBACH, ARNULF |
分类号 |
C07D223/10;A61K31/55;A61K31/5513;A61K45/00;A61K45/06;A61P3/10;A61P5/18;A61P7/00;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P29/00;A61P31/00;A61P31/12;A61P33/00;A61P35/00;A61P43/00;C07D263/48;C07D277/08;C07D307/68;C07D333/38;C07D401/12;C07D401/14;C07D403/12;C07D409/12;C07D409/14;C07D413/12;C07D417/12;C07D417/14;C07D471/04;C07D495/04;C07K5/023 |
主分类号 |
C07D223/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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