| 摘要 |
The present invention relates to compounds of the general formula R is lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is halogen or hydrogen; and when p is 1, R1 in addition to the above substituents may be taken together with R1 to form -CH=CH-CH=CH-, R2 and R2' are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano; and when n is 1, R2 and R2' may in addition to the above substituents form -CH=CH-CH=CH-, unsubstituted or substituted by one or two substituents selected from lower alkyl or lower alkoxy; R3 and R3' are hydrogen, lower alkyl or taken together with the attached carbon atom form a cycloalkyl group; R4 is hydrogen, -N(R5)2, -N(R5)(CH2)nOH, -N(R5)S(O)2-lower alkyl, N(R5)S(O)2-phenyl, -N=CH-N(R5)2, -N(R5)C(O)R5; R5 is hydrogen, C3-6-cycloalkyl, benzyl or lower alkyl; R6 is hydroxy, lower alkyl; -(CH2)nCOO-(R5), -N(R5)CO-lower alkyl, hydroxy-lower alkyl;-(CH2)qCN; -(CH2)nO(CH2)nOH, -CHO or a 5-or 6 membered heterocyclic ring containing from 1 to 4 heteroatoms, selected from the group consisting of oxygen, nitrogen, and sulfur, and with one of the carbon atoms in said ring being unsubstituted or substituted with an oxo group, which heterocyclic ring is directly bonded or bonded via an alkylene group, to the remainder of the molecule; is a cyclic tertiary amine which may contain one additional heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur wherein any sulfur present in the ring is thio or can be oxidized to sulfoxide or sulfur dioxide, by which said cyclic tertiary amine is directly attached to the remainder of the molecule or is attached through the linker -(CH2)nN(R5)-; X is -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R<h
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