A TRANSMEMBRANE PROTEIN AS A DOWNSTREAM TARGET OF NEUROTROPHIN AND EPHRIN RECEPTOR TYROSINE KINASES, DNA ENCODING SAME AND MONOCLONAL ANTIBODIES THERETO

摘要

The present invention relates to an ankyrin repeat-rich membrane spanning (ARMS) polypeptide which is a downstream target of neurotrophin and ephrin receptor tyrosine kinases. This ARMS polypeptide contains 1715 amino acid residues including four transmembrane domains, multiple ankyrin repeats, a sterile a motif domain, and a PDZ-binding motif. Immunofluorescence studies with anti-ARMS antibodies have found ARMS to be localized discreetly to the growth cone of neurons.