发明名称 |
SUBSTITUTED CARBOXYLIC ACID DERIVATIVES |
摘要 |
Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor a (PPARa) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preventing effect, an anti-obesity effect, a hypoglycemic effect, etc.; and a process for producing the same. Namely, substituted carboxylic acid derivatives represented by the following general formula (1) and pharmaceutically acceptable salts and hydrates of the same; and a process for producing these compounds: (1) wherein R<1>, R<3> and R<5> represent each hydrogen or lower alkyl; R<2> represents hydrogen or lower alkoxy; R<4> represents hydrogen, trifluoromethyl, lower alkoxy, halogeno, optionally substituted phenoxy or benzyloxy; n is an integer of from 0 to 3; and the carboxylate substituent is located at the p-position concerning R<2> or at the p-position concerning (CH2)n.
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申请公布号 |
WO0246146(A1) |
申请公布日期 |
2002.06.13 |
申请号 |
WO2001JP10563 |
申请日期 |
2001.12.04 |
申请人 |
KYORIN PHARMACEUTICAL CO., LTD.;MIYACHI, HIROYUKI;TAKAHASHI, YUKIE;MURAKAMI, KOUJI |
发明人 |
MIYACHI, HIROYUKI;TAKAHASHI, YUKIE;MURAKAMI, KOUJI |
分类号 |
A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P43/00;C07C275/30;C07C275/42;(IPC1-7):C07C275/28;A61K31/195;A61K31/216;C07C275/34 |
主分类号 |
A61P3/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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