发明名称 |
Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
摘要 |
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
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申请公布号 |
US6399789(B1) |
申请公布日期 |
2002.06.04 |
申请号 |
US20000548060 |
申请日期 |
2000.04.12 |
申请人 |
KOSAN BIOSCIENCES, INC. |
发明人 |
SANTI DANIEL V.;XUE QUN;ASHLEY GARY |
分类号 |
C07B61/00;C07H17/08;C12N9/00;C12N9/10;C12N9/12;C12N15/52;C12N15/70;C12N15/76;C12N15/81;C12P7/26;C12P7/42;C12P17/08;C12P19/62;(IPC1-7):C07D313/16 |
主分类号 |
C07B61/00 |
代理机构 |
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