发明名称 |
Compound possessing potent thrombin receptor antagonist activity |
摘要 |
The subject invention concerns eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol. This compound can be isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist and, furthermore, inhibits human platelet aggregation. Longer chain penasterol oligosaccharides were also isolated and characterized but these had weaker activity than eryloside F. The subject invention also concerns methods for inhibiting thrombin receptor activity and methods for inhibiting platelet aggregation through the administration of eryloside F, or a salt, derivative or analog thereof.
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申请公布号 |
US6399581(B1) |
申请公布日期 |
2002.06.04 |
申请号 |
US20000568694 |
申请日期 |
2000.05.11 |
申请人 |
HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.;GLAXO WELLCOME INC. |
发明人 |
STEAD PAUL;WRIGHT AMY E.;POMPONI SHIRLEY A.;LANGLEY DAVID |
分类号 |
A61K31/70;(IPC1-7):A01N43/04;G01N33/53;A16K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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