Compounds of the invention have the structure D-L-A*, where L is a linking moiety that maintains D and A in a configuration compatible with FRET, D is a fluorescent donor moiety capable of causing an acceptor moiety to fluoresce by FRET, and A* is a fluorescent acceptor moiety capable of accepting energy from the donor moiety by FRET and fluorescing only after cleavage of one or more labile groups to provide acceptor A. These compounds are useful as fluorescent substrates for detection of enzymes in vivo.
申请公布号
WO0136662(A3)
申请公布日期
2002.05.30
申请号
WO2000US41908
申请日期
2000.11.03
申请人
ICONIX PHARMACEUTICALS, INC.;JARNIGAN, KURT;LEGER, ROGER;LEE, VING, J.;MORGANS, DAVID
发明人
JARNIGAN, KURT;LEGER, ROGER;LEE, VING, J.;MORGANS, DAVID