| 摘要 |
The present invention is directed to a novel class of cyclic polypeptides of the formula: (R<SUP>1</SUP>)<SUB>a</SUB>-AA<SUP>1</SUP>-cyclo[AA<SUP>2</SUP>-AA<SUP>3</SUP>-AA<SUP>4</SUP>-AA<SUP>5</SUP>-AA<SUP>6</SUP>-Cys]-AA<SUP>7</SUP>-R<SUP>2</SUP>, pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification, which inhibit the effects of urotensin-II and are useful for treating a variety of diseases and/or conditions characterized by an excess of urotensin-II including ischaemic heart disease, congestive heart failure, portal hypertension, variceal bleeding, hypotension, angina pectoris, myocardial infarction, ulcers, anxiety, schizophrenia, manic depression, delirium, dementia, mental retardation and/or dyskinesias. |
