| 摘要 |
<p>The present invention relates to aqueous solution formulation containing interferon alfa-2b (IFN), which maintains inreased thermal stability and is resistant for autooxidation, and process for making thereof. The formulation comprises (0,01-50) x 106 IU/ml of interferon alfa-2b, 0,08 to 0,1 M of sodium citrates, 0,05 to 0,06 M of glycine, 0,008 to 0,01 % of polysorbate-20, 0,004 to 0,005 % of thimerosal. The pH of solution is maintained as high as 6,0 0,1. This inventon can be used in manufacture of IFN stable, aqueous solution formulation for treatment of some viral and oncological diseases or/and in biotechnology processes for manufacture of genoengineering IFN.</p> |
