| 摘要 |
<p>Therapeutic composition for treatment of AIDS is disclosed, and the method producing the agent is also disclosed. The composition for treatment of AIDS of the invention substantially comprise at least a monoclonal antibody to which the antigen is ELDKWA neutralizing epitope on the human immune deficiency associated virus transmembrane protein gp41 or the variants thereof, and the said variant epitopes are ELEKWA,ELNKWA, ELDEWA. The method producing the agent comprise: (1) artificially synthesis of at least a strand of peptide containing neutralizing epitope ELDKWA on the human immue deficiency associated virus transmembrane protein gp41 and/or the variants thereof; (2) coupling the said peptides to a carrier protein or a carrier polypeptide individually; (3) immunizing an animal with the conjugate; (4) producing hybridoma; (5) mixing the four neutralizing antibodies to obtain the composition.</p> |
