发明名称 |
MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION |
摘要 |
The disclosed invention is a composition for and a method of treating a <i>Flaviviridae</i> (including BVDV and HCV), <i>Orthomyxoviridae </i> (including Influenza A and B) or <i>Paramyxoviridae</i> (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ("TR-PCR"). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample. |
申请公布号 |
WO0232920(A2) |
申请公布日期 |
2002.04.25 |
申请号 |
WO2001US46113 |
申请日期 |
2001.10.18 |
申请人 |
PHARMASSET LIMITED;STUYVER, LIEVEN;WATANABE, KYOICHI, A. |
发明人 |
STUYVER, LIEVEN;WATANABE, KYOICHI, A. |
分类号 |
C07D473/18;A61K31/513;A61K31/52;A61K31/522;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61P3/12;A61P31/12;A61P35/00;A61P35/02;C07D405/04;C07D473/30;C07D473/34;C07H19/048;C07H19/06;C07H19/067;C07H19/10;C07H19/16;C07H19/167;C07H19/20;C07H21/04;C12Q1/68 |
主分类号 |
C07D473/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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