发明名称 |
PROCESS FOR PRODUCING NUCLEIC ACID DERIVATIVES |
摘要 |
There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or allowing halogenated derivatives in the sugar-moiety, in the nucleic acids or in derivatives thereof to react with any one of hypophosphorous acids (including salts thereof) and phosphites (esters) which are inexpensive, non-toxic and safely usable as radical reducing agents in industrial scale, in the presence of a radical reaction initiator. The process of the present invention is an industrially useful and highly safe process for reducing sugar-moiety hydroxyl groups and halogen atoms in nucleic acids or derivatives thereof (including nucleic acid-related compounds) at low costs.
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申请公布号 |
US2002045744(A1) |
申请公布日期 |
2002.04.18 |
申请号 |
US19990427082 |
申请日期 |
1999.10.26 |
申请人 |
TAKAMATSU SATOSHI;KATAYAMA SATOSHI;HIROSE NAOKO;IZAWA KUNISUKE |
发明人 |
TAKAMATSU SATOSHI;KATAYAMA SATOSHI;HIROSE NAOKO;IZAWA KUNISUKE |
分类号 |
C07H19/04;(IPC1-7):C07H23/00 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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