发明名称 |
Therapeutic inhibitor of vascular smooth muscle cells |
摘要 |
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
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申请公布号 |
US2002040064(A1) |
申请公布日期 |
2002.04.04 |
申请号 |
US20010910387 |
申请日期 |
2001.07.20 |
申请人 |
NEORX CORPORATION. |
发明人 |
KUNZ LAWRENCE L.;KLEIN RICHARD A. |
分类号 |
A61F2/82;A61K9/00;A61K31/00;A61K31/04;A61K31/131;A61K31/135;A61K31/138;A61K31/165;A61K31/17;A61K31/335;A61K31/337;A61K31/352;A61K31/365;A61K31/40;A61K31/4025;A61K31/4035;A61K31/407;A61K31/519;A61K31/551;A61K31/704;A61K47/48;A61L31/16;A61P9/08;(IPC1-7):A61K31/135 |
主分类号 |
A61F2/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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