发明名称 |
PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF STROKE AND TRAUMATIC BRAIN INJURY |
摘要 |
This invention relates to methods of treating traumatic brain injury (TBI) o r hypoxic or ischemic stroke, comprising administering to a patient in need of such treatment an NR2B subtype selective N-methyl-D-aspartate (NMDA) receptor antagonist in combination with either: (a) a neutrophil inhibitory factor (NIF); (b) a sodium channel antagonist; (c) a nitric oxide synthase (NOS) inhibitor; (d) a glycine site antagonist; (e) a potassi um channel opener; (f) an AMPA/kainate receptor antagonist; (g) a calcium channel antagonist; ( h) a GABA-A receptor modulator (e.g., a GABA-A receptor agonist); or (i) an antiinflammatory agent.
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申请公布号 |
CA2356557(A1) |
申请公布日期 |
2002.03.06 |
申请号 |
CA20012356557 |
申请日期 |
2001.09.04 |
申请人 |
PFIZER PRODUCTS INC., |
发明人 |
MENNITI, FRANK SAMUEL;CHENARD, BERTRAND LEO;SALTARELLI, MARIO DAVID |
分类号 |
A61K45/06;A61K31/05;A61K31/075;A61K31/353;A61K31/40;A61K31/435;A61K31/445;A61K31/451;A61K31/453;A61P9/00;A61P9/10;A61P43/00;(IPC1-7):A61K31/445 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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