发明名称 |
Process for the preparation of 5-methoxy-4-(methylthioalkyl) 1, 3-bis(phenylmethyl)-2-imidazolidone |
摘要 |
This invention provides a process for the preparation of 5-methoxy-4-(methylthioalkyl)-1,3-bis(phenylmethyl)-2-imidazolidone having general formula (2a-d)[wherein R=-CH2COCH2CH2CH2COOMe (2a); -CH2CH(OMe)2(2b); -CH2COOMe(2c); -H (2d)] which comprises reacting a reducing agent with 6-benzyl-7-methoxy-3-phenylperhydroimidazo[1,5-c][1.3]thiozol-5-one in the presence of an organic solvent for a period ranging from 0.5 to 2 hrs at a temperature ranging from -78° C. to 80° C., evaporating the solvent and reacting the residue with an alkylating reagent, optionally in the presence of a phase transfer catalyst and an inorganic base in an organic solvent for a period ranging from 10-12 hrs at room temperature, evaporating the solvent followed by purification to obtain the desired compound of general formula 2 a-d.
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申请公布号 |
US6350881(B1) |
申请公布日期 |
2002.02.26 |
申请号 |
US20000724501 |
申请日期 |
2000.11.28 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH |
发明人 |
CHAVAN SUBHASH PRATAPRAO;KAMAT SUBHASH KRISHNAJI;RAI BEENA;SIVADASAN LATHA;BALAKRISHNAN KAMALAM;SADYANDI RAMALINGAM;CHITTIBOYINA AMAR GOPAL;DESHPANDE VISHNU HARI |
分类号 |
C07D513/04;(IPC1-7):C07D233/30 |
主分类号 |
C07D513/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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