Verfahren zur enantioselektiven Reduktion von 8-Chlor-6oxo-octansäurealkylestern

摘要

The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of general formula (R)-II or (S)-II, where R = C>1-4< alkyl, from 8-chloro-6-oxo-octanoic acid alkyl esters of general formula (I), where R has the above meaning. The production of the desired enantiomers is achieved biocatalytically by means of an enantioselective reaction, whereby the strains Mucor racemosus for (S)-II compounds and Geotrichum candidum for (R)-II compounds are used. The esters thus obtained can be sterospecifically converted to (R)- alpha -lipoic acid by conventional methodology.