A novel method and assays for yeast-based drug screening

摘要

The present invention provides a method wherein yeast mutants deficient in the expression of the yeast homolog of frataxin are applied for the identification and/or evaluation of pharmaceutically active compounds. The invention concerns especially a method wherein the yeast strain W303-1B/Deltaydl120w::Kan^R is applied for the identification and/or evaluation of chemical and biochemical compounds that protect W303-1B/Deltaydl120w::Kan^R yeast from chemical stress. Furthermore, the invention concerns the application of said method in new cell-based assays to be used for drug screening.