BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS

摘要

PCT No. PCT/JP96/01533 Sec. 371 Date Dec. 9, 1997 Sec. 102(e) Date Dec. 9, 1997 PCT Filed Jun. 6, 1996 PCT Pub. No. WO96/41795 PCT Pub. Date Dec. 27, 1996This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is lower alkoxy, etc., R5 is hydrogen, etc., A is NH, etc., E is etc., X is -CH=CH-, -CH=N-, or S, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.