| 发明名称 |
NOVEL FIBROBLAST GROWTH FACTOR (FGF23) AND METHODS FOR USE |
| 摘要 |
<p>The invention relates to novel nucleic acids encoding a fibroblast growth factor-23 (FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic disorders comprising inhibiting or stimulating, respectively, the biological activity of FGF23 in a patient. The invention also relates to methods of treating osteoporosis, dermatomyositis, and coronary artery disease comprising stimulating the biological activity of FGF23 in a patient.</p> |
| 申请公布号 |
CA2418215(A1) |
申请公布日期 |
2002.01.31 |
| 申请号 |
CA20012418215 |
申请日期 |
2001.07.10 |
| 申请人 |
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE;LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN ABTEILUNG MEDIZINISCHE GENETIK |
发明人 |
STROM, TIM MATTHIAS;MEITINGER, THOMAS;WHITE, KEN;ECONS, MICHAEL |
| 分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K38/18;A61K38/22;A61K39/395;A61K45/00;A61K48/00;A61P3/12;A61P13/12;A61P17/00;A61P19/04;A61P19/08;A61P19/10;A61P21/00;C07K14/50;C07K16/24;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12N15/16;C12N15/18;C12P21/02;C12P21/08;C12Q1/68;(IPC1-7):C12N15/18;A61K38/16;A61K38/17;C07K16/22;C07K16/26;C07K14/435;C07K14/47;C07K14/475;G01N33/53;G01N33/567;C12N15/62;C12N15/63 |
主分类号 |
A01K67/027 |
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