| 摘要 |
<p>A compound which is an arylsulfonyl propanoic acid derivative of formula (I) : CH2R1 XC(O)-C(OH)-SO2-C6H4-N(R2)COA (I) wherein X is HO-NH- or HO- , R1 is selected from -O-Ph, -S-Ph, -S-Het, -Hyd or -CH2-Hyd, wherein Ph is a phenyl group; Het is a heterocyclic ring and Hyd is a substituted hydantoin-3-yl ring; A is a phenyl group or Het as defined above, or a condensed phenyl ring; and R2 is either hydrogen or methyl; or R2 represents a methylene (-CH2-) bridge connecting the N atom to the ortho position of said A to form a 5-membered lactam; or a salt or an oral prodrug thereof.The compounds are inhibitors of matrix metallo-proteinases (MMPs) and are therefore useful in the prevention, control and treatment of diseases in which MMPs are involved.</p> |
