Preparation and use of particulates composed of adenovirus particles

摘要

This invention provides particulates of adenoviral particles comprised of individual adenovirus virions complexed to an insoluble micro-platform material and for such compositions further comprised of a polynucleotide encoding an antigenic peptide. The invention further provides method for forming such complexes such that the compositions are useful for transfecting phagocytic antigen presenting cells such as dendritic cells and for vaccinating a subject against disease.