发明名称 |
Synthesis of histamine dihydrochloride. |
摘要 |
The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% <SMALLCAPS>L</SMALLCAPS>-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use. |
申请公布号 |
ZA200104552(B) |
申请公布日期 |
2002.01.16 |
申请号 |
ZA20010004552 |
申请日期 |
2001.06.04 |
申请人 |
MAXIMUM PHARMACEUTICALS INC. |
发明人 |
WEN-LUNG YEH;CASIMIR ANTCZAK;JEFFRY DAVID MCGOLRICK;MICHEAL JOSEPH ROTH;MARK WRONA |
分类号 |
C07D233/64;A61K36/886;C07D;C07D233/54;C07D233/61 |
主分类号 |
C07D233/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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