发明名称 |
Viral specific requirements for self-priming RNA replication of hepatitis C virus replicase |
摘要 |
The present invention relates to identification of the features of an RNA template that provide for efficient "copy-back" self-priming activity of hepatitis C virus replicase. This activity can be used to screen for anti-HCV replicase compounds, or to characterize the biological relevance of lead compounds that have already been identified. The specific features of the optimal RNA templates can be used for developing a system to characterize HCV NS5B polymerase mechanistically and kinetically, and for designing small RNA molecules to co-crystallize with HCV NS5B polymerase.
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申请公布号 |
US6322966(B1) |
申请公布日期 |
2001.11.27 |
申请号 |
US19990309670 |
申请日期 |
1999.05.11 |
申请人 |
ZHONG WEIDONG;HONG ZHI;LAU JOHNSON Y. N. |
发明人 |
ZHONG WEIDONG;HONG ZHI;LAU JOHNSON Y. N. |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/70 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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