METHOD FOR PRODUCING QUINOLINECARBOALDEHYDE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing 2-cyclopropyl-4-(4-fluorophenyl)- quinoline-3-carboaldehyde important as an intermediate for synthesizing medicaments. SOLUTION: This method for producing 2-cyclopropyl-4-(4-fluorophenyl)- qulinoline-3-carboaldehyde of formula (2) is characterized by comprising oxidation of 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline of formula (1) with an oxygen-containing gas in the presence of a bivalent palladium salt and a pyridine compound.