发明名称 |
POLYNUCLEOTIDES ENCODING FOR POLYMORPHIC ISOFORMS OF THE PTHrP PROTEIN, THE ENCODED PROTEINS AND THEIR THERAPEUTIC APPLICATIONS THEREOF |
摘要 |
Described herein is the identification of two polymorphic isoforms of the gene encoding the PTHrP protein, of the allelic proteins, of a first polynucleotide comprising the polymorphic domain corresponding to SEQ ID NO:2 and comprising a first polymorphic position, of a second polynucleotide comprising a second polymorphic domain and corresponding to SEQ ID NO:7 which encode for two variants of the PTHrP protein; also described is the use of these genes, alleles or polynucleotides to determine the risk of tumor in animals and humans and genetically modified cells and non-human animals. |
申请公布号 |
WO0185784(A2) |
申请公布日期 |
2001.11.15 |
申请号 |
WO2001EP05413 |
申请日期 |
2001.05.11 |
申请人 |
ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI;DRAGANI, TOMMASO, A.;MANENTI, GIACOMO |
发明人 |
DRAGANI, TOMMASO, A.;MANENTI, GIACOMO |
分类号 |
A01K67/027;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P3/14;A61P5/18;A61P35/00;C07K14/635;C07K16/26;C12N15/09;C12Q1/68;G01N33/53;G01N33/566;G01N33/574;(IPC1-7):C07K14/635 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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