发明名称 |
MELT-EXTRUSION MULTIPARTICULATES |
摘要 |
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
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申请公布号 |
US2001033865(A1) |
申请公布日期 |
2001.10.25 |
申请号 |
US19990358828 |
申请日期 |
1999.07.22 |
申请人 |
OSHLACK BENJAMIN;HUANG HUA-PIN;CHASIN MARK |
发明人 |
OSHLACK BENJAMIN;HUANG HUA-PIN;CHASIN MARK |
分类号 |
A61K;A61K9/14;A61K9/16;A61K9/20;A61K9/22;A61K9/26;A61K9/52;A61K31/135;A61K31/485;A61K47/00;A61K47/10;A61K47/12;A61K47/32;A61K47/38;A61K47/44;A61K47/46;(IPC1-7):A61K9/52 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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