<p>The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% <SMALLCAPS>L</SMALLCAPS>-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.</p>
申请公布号
EP1140857(A1)
申请公布日期
2001.10.10
申请号
EP19990968148
申请日期
1999.12.20
申请人
MAXIM PHARMACEUTICALS, INC.
发明人
YEH, WEN-LUNG;ANTCZAK, CASIMIR;MCGOLRICK, JEFFRY, DAVID;ROTH, MICHAEL, JOSEPH;WRONA, MARK