2-[INDANYLAMINO]PYRIMIDONE AND 2-[TETRAHYDRONAPHTHALENYLAMINO]PYRIMIDONE DERIVATIVES

摘要

The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: wherein R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or 1 to 3 substituents selected from a C1-6 alkyl group, halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, methylenedioxy group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, C2-10 dialkylamino group; C0-6 alkylcarbonylamino group, C6,10 arylcarbonylamino group; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or a halogen atom and n represents 0 or 1, when n represents 0 then m is 2 or 3, and when n represents 1 then m is 1 or 2. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta such as Alzheimer's disease.