发明名称 |
Multilayer pharmaceutical product for release in the colon |
摘要 |
The invention relates to the use of a multilayer pharmaceutical product that substantially comprises a) a core containing a pharmaceutically active substance, b) an inner coating consisting of a copolymer or a mixture of copolymers that are composed of 85 to 98 wt.- % of radically polymerized C1 to C4 alkyl esters of the acrylic or methacrylic acid and 15 to 2 wt.- % of (meth)acrylate monomers with a quaternary ammonium group in the alkyl group, and c) an outer coating consisting of a copolymer that is composed of 75 to 95 wt.- % of radically polymerized C1 to C4 alkyl esters of the acrylic or methacrylic acid and 5 to 25 wt.- % of (meth)acrylate monomers with an anionic group in the alkyl group. The inventive product is used for producing a pharmaceutical product that releases the active substance contained therein according to the USP release test, at pH 1.2 during 2 hours and subsequent rebuffering to pH 7.0, by less than 5% after 2.0 hours after start of the test and by 30 to 80% after eight hours after start of the test.</PTEXT> |
申请公布号 |
AU3928501(A) |
申请公布日期 |
2001.09.24 |
申请号 |
AU20010039285 |
申请日期 |
2001.03.09 |
申请人 |
ROHM GMBH AND CO. KG |
发明人 |
THOMAS BECKERT;HANS-ULRICH PETEREIT;VISHAL K. GUPTA |
分类号 |
A61K47/32;A61K9/16;A61K9/28;A61K9/32;A61K9/50;A61K9/58;A61K31/194;A61K31/4402;A61K31/573;A61K31/606;A61P1/14;A61P3/02;A61P3/10;A61P5/00;A61P5/18;A61P5/44;A61P29/00;A61P31/00;A61P31/04;A61P43/00 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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