| 摘要 |
<p>Novel alcohols of the general formulae <FORM:1109190/C2/1> and <FORM:1109190/C2/2> (wherein R00 represents a methylene or ethylidene radical, R** a C1- 5 alkyl radical, Rp a cyclohexyl, cyclopentyl or C1- 5 alkyl radical and Rm a halogen atom or a C1- 5 alkoxy or alkylthio trihalomethyl, SH, NH2, di-(C1- 5 alkyl)-amino, CN, ND2, CONH2, C1- 6 alkanoylamino, C1- 4 alkylsulphonyl, di-(C1- 5 alkyl)-sulphamoyl or OH radical, and x is 1 or 2, with the provisos that at least one Rm substituent is in one of the m-positions relative to the side chain, and that there is at most one trihalomethyl substituent which must be in such m-position) are prepared by reducing the corresponding carboxylic acids (containing -COOH in place of -CH2OH), preferably by means of an alkali or alkaline-earth metal aluminium hydride. The alcohols may be converted to their alkyl or ethoxyethyl ethers by the action of alkylating or ethoxyethylating agents. Pharmaceutical compositions, having anti-inflammatory activity, contain the novel alcohols and ethers as active ingredients.</p> |
