| 摘要 |
1,169,658. 2 - (4 - Benzyl - 1 - piperidyl)- ethylguanidine and salts. SOC. ANON DES LABORATORIES ROBERT ET CARRIERE. 5 Jan., 1968 [6 Jan., 1967], No. 874/68. Heading C2C. The novel compound 2-(4-benzyl-1-piperidyl)- ethylguanidine (and its pharmaceutically acceptable acid addition salts, e.g. the dihydrochloride, sulphate, nitrate, tartrate, citrate, succinate or ascorbate) is prepared, in accordance with the invention, by condensing (a) S-methylisothiourea or an acid addition salt thereof, O-methylisourea or an acid addition salt thereof, 3,5 - dimethyl - 1 - guanyl - pyrazole or an acid addition salt thereof, cyanamide, dicyandiamide, or calcium cyanamide, with (b) 2-(4-benzyl.1- piperidyl) ethylamine or an acid addition salt thereof. 2-(4-Benzyl. 1 -piperidyl) ethyldmine is prepared by reduction of (4-benzyl-1-piperidyl)- acetonitrile which is obtained by reacting chloroacetonitrile with 4-benzyl piperidine. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration comprise an above novel compound or salt and a diluent and have hypotensive properties. |
