发明名称 |
PYRROLOPYRIDAZINE COMPOUND |
摘要 |
A pyrrolopyridazine compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R<1> is C2-6 alkenyl, C2-6 halogenoalkenyl, optionally substituted C3-7 cycloalkyl, or optionally substituted C1-6 alkyl substituted by C3-7 cycloalkyl; R<2> is C1-6 alkyl; R<3> is hydroxymethyl, C2-6 aliphatic acyloxymethyl, optionally substituted (C6-10 aryl)carbonyloxymethyl, (C1-6 alkoxy)carbonyloxymethyl, formyl, carboxy, (C1-6 alkoxy)carbonyl, or optionally substituted (C6-10 aryl)oxycarbonyl; R<4> is optionally substituted C6-10 aryl; and A is imino, oxygen, or sulfur.) The pyrrolopyridazine compound is highly effective in inhibiting the secretion of gastric hydrochloric acid, protecting the gastric mucosa, and the like. It is useful as a medicine, especially a preventive/remedy for ulcerative diseases.
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申请公布号 |
WO0158901(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
WO2001JP00820 |
申请日期 |
2001.02.06 |
申请人 |
SANKYO COMPANY, LIMITED;UBE INDUSTRIES, LTD.;IWABUCHI, HARUO;HAGIHARA, MASAHIKO;SHIBAKAWA, NOBUHIKO;MATSUNOBU, KEIJI;FUJIWARA, HIROSHI |
发明人 |
IWABUCHI, HARUO;HAGIHARA, MASAHIKO;SHIBAKAWA, NOBUHIKO;MATSUNOBU, KEIJI;FUJIWARA, HIROSHI |
分类号 |
A61K31/5025;A61P1/04;C07D207/00;C07D237/00;C07D487/04;(IPC1-7):C07D487/04;A61K31/502 |
主分类号 |
A61K31/5025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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