发明名称 |
Topoisomerase I |
摘要 |
Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
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申请公布号 |
US6274139(B1) |
申请公布日期 |
2001.08.14 |
申请号 |
US19990340479 |
申请日期 |
1999.06.30 |
申请人 |
SMITHKLINE BEECHAM CORPORATION;SMITHKLINE BEECHAM P.L.C. |
发明人 |
GWYNN MICHAEL N.;KALLENDAR HOWARD;PALMER LESLIE M. |
分类号 |
G01N33/53;A61K38/00;A61K38/45;A61K38/55;A61K39/00;A61K48/00;A61P31/04;C07K14/81;C12N5/00;C12N5/10;C12N9/90;C12N15/09;C12N15/61;C12P21/08;C12Q1/68;C12R1/91;G01N33/531;G01N33/566;(IPC1-7):A61K38/51;C12Q1/58 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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