发明名称 |
Interaction of nmda receptor with protein tyrosine phosphatase |
摘要 |
The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and a protein tyrosine phosphatase (PTP), e.g., PTPL1. The present invention provides methods for screening a PTPL1 agonist or antagonist that modulates NMDA-R signaling. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling. The present invention further provides methods for isolating PTPL1 from a biological preparation. |
申请公布号 |
AU3659101(A) |
申请公布日期 |
2001.08.14 |
申请号 |
AU20010036591 |
申请日期 |
2001.01.30 |
申请人 |
AGY THERAPEUTICS, INC. |
发明人 |
THORSTEN MELCHER;KALEV KASK |
分类号 |
G01N33/50;A61K45/00;A61P9/10;A61P25/00;A61P25/04;A61P25/08;A61P25/14;A61P25/18;A61P25/28;A61P25/30;A61P25/32;A61P41/00;A61P43/00;C12Q1/42;G01N33/15;G01N33/94 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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