Xanthine derivatives with end-aminated alkynol side chains

摘要

omega -Amino-hydroxyalkynyl substituted xanthine derivatives of formula (I) are new: R<1> and/or R<3> = group of formula (a) or (b); and when only one of R<1> and R<3> is group (a) or (b) the other is H or R<8>; R<8> = 1-6C alkyl, 3-6C cycloalkyl or 4-8C cycloalkyl-alkyl; R<2> = 1-5C alkyl, 3-6C cycloalkyl or 4-8C cycloalkyl-alkyl; R<4> = H or 1-3C alkyl; R<5>-R<7> = H, 1-6C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl-alkyl, Ar-1-2C alkyl or tri(1-4C alkyl)silyl; or NR<5>R<6> = 4-7 membered saturated ring optionally substituted by 1-4 1-4C alkyl and/or containing O, S, SO, SO2 or NR<13> in place of 1 CH2; R<13> = H, 1-3C alkylcarbonyl or 1-4C alkyl; A = 1-6C alkylene; Z<-> = inorganic or organic acid anion.