GYRASE INHIBITORS AND USES THEREOF

摘要

Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grpl, and at least two features selected from Grp2, Grp3 or Grp4 in which HBA is a hydrogen bond acceptor, HBD is a hydrogen bond donor, and Grps 1-4 are as described in the specification. The compounds are inhibitors of bacterial DNA gyrase and are useful in treating bacterial infections. The pharmacophore features may be used to identify and design new inhibitors.