AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES

摘要

Compounds of formula (I) and pharmaceutically acceptable salts thereof. As used in formula (I), and throughout the specification, the symbols have the following meanings: R1 and R2 are independently hydrogen, fluorine or alkyl; R3 is aryl or heteroaryl, R4 has various meanings; R5 is hydrogen or alkyl; m is an integer of 0 to 2; and n is an integer of 1 to 3. The compounds of formula (I) are protein kinase inhibitors and are useful in the treatment an d prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's diseases cardiovascular diseases, viral disease s and fungal diseases.