发明名称 |
BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS |
摘要 |
Bissulfonamide derivatives of formula (I) are capable of inhibiting: a) the biosynthesis of aromatic amino acids via the shikimate pathway and b) the catabolism of quinic acid, wherein: Ar is an aryl or heteroaryl group; R1 and R2 are the same or different and each represent hydrogen or alkyl or R1 and R2 together form a C1-C3 alkylene group, -CO- or -CS-; and R3 and R4 are the same or different and each represent -alkyl-aryl, -alkyl-heteroaryl, -alkenyl-aryl, -alkenyl-heteroaryl, -alkynyl-aryl-alkynyl-heterorayl, aryl or heteroaryl.
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申请公布号 |
WO0128537(A3) |
申请公布日期 |
2001.06.14 |
申请号 |
WO2000GB03944 |
申请日期 |
2000.10.13 |
申请人 |
ARROW THERAPEUTICS LIMITED;MADGE, DAVID;WISHART, GRANT;DOLMAN, MARK;MAUNDER, PETER |
发明人 |
MADGE, DAVID;WISHART, GRANT;DOLMAN, MARK;MAUNDER, PETER |
分类号 |
C07D239/74;A01N41/06;A61K31/145;A61K31/18;A61K31/381;A61K31/422;A61K31/425;A61K31/426;A61K31/4436;A61K31/517;A61L2/18;A61P31/04;A61P31/10;A61P33/06;A61P43/00;C07C311/13;C07C311/21;C07C311/29;C07C311/46;C07C317/14;C07D333/34;C07D409/04;C07D413/04;C07D417/04;(IPC1-7):A61K31/18 |
主分类号 |
C07D239/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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