A MULTISTAGE PROCESS FOR THE PREPARATION OF HIGHLY PURE DEFEROXAMINE MESYLATE SALT
摘要
The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.
申请公布号
WO0140164(A1)
申请公布日期
2001.06.07
申请号
WO2000US32574
申请日期
2000.11.30
申请人
BIOGAL GYOGYSZERGYAR RT;TEVA PHARMACEUTICALS USA, INC.;KERI, VILMOS;CZOVEK, ZOLTAN;MEZO, ATTILA