AN ANIMAL MODEL FOR STUDYING HORMONE SIGNALLING AND METHOD OF MODULATING THE SIGNALLING
摘要
The present invention relates generally to a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in hormone signalling. The present invention further provides an animal model useful for screening for agents capable of agonizing or antagonizing hormone signalling. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of conditions arising from or otherwise associated with aberrations in growth hormone signalling. The present invention further comprises a genetically modified animal. More particularly, the animals are genetically modified such that they have altered growth hormone signalling. The genetically modified animals of the present invention range from laboratory animals useful <i>inter alia</i> for animal models for studying hormone regulation and for the development of therapeutic protocols predicated, in part, on modulating hormone signalling to livestock animals. The latter may be manipulated for improved food production.
申请公布号
WO0135732(A1)
申请公布日期
2001.05.25
申请号
WO2000AU01398
申请日期
2000.11.16
申请人
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;ALEXANDER, WARREN, SCOTT;METCALF, DONALD;GREENHALGH, CHRISTOPHER, JOHN
发明人
ALEXANDER, WARREN, SCOTT;METCALF, DONALD;GREENHALGH, CHRISTOPHER, JOHN