发明名称 Non-human animal model for systemic lupus erythematosis
摘要 A specific method has been developed to produce an autoimmune response and resulting clinical symptoms for a particular disease process. Peptides or other structures derived from an autoantigen and which are bound by auto antibody or T cell receptors are identified and used to induce an immune response. This immune response evolves into an autoimmune response directed against the other portions of the protein from which the peptide was derived. Subsequently, clinical manifestations may appear that are also found in the clinical illness. selected from the group including viruses, bacteria, fungi, parasites, rickettsia, plasmids, and insects which contains a structure or a peptide sequence that is similar to a structure or peptide sequence that has been identified by the method of claim 1 to the extent that it is bound by one of the group selected from antigen specific B cell surface receptors, and antigen specific T cell receptors.
申请公布号 US6232522(B1) 申请公布日期 2001.05.15
申请号 US19930160604 申请日期 1993.11.30
申请人 OKLAHOMA MEDICAL RESEARCH FOUNDATION 发明人 HARLEY JOHN B.;JAMES JUDITH A.;SCOFIELD R. HAL
分类号 A61K38/00;A61K39/00;C07K14/145;C07K14/47;G01N33/564;G01N33/569;G01N33/68;(IPC1-7):C07K5/00;C12N15/85 主分类号 A61K38/00
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