| 发明名称 |
Signal sequences for the production of leu-hirudine via secretion by e. coli in a culture medium |
| 摘要 |
The present invention relates to a efficient expression of a protein, particularly, hirudin; a protein precursor comprising a signal sequence and the sequence of aa<SUB>X</SUB>-hirudin, wherein aa<SUB>X </SUB>is a selected amino acid, and aa<SUB>X </SUB>is preferably leucine; to its preparation and use; and to processes for finding signal sequences for secretory expression of any desired protein in E coli; and to processes for the secretory expression of any desired protein in E coli. |
| 申请公布号 |
AU6842100(A) |
申请公布日期 |
2001.04.24 |
| 申请号 |
AU20000068421 |
申请日期 |
2000.09.01 |
| 申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
PAUL HABERMANN;RUDOLF BENDER |
| 分类号 |
G01N33/50;A61P7/02;C07K14/21;C07K14/24;C07K14/245;C07K14/815;C12N1/21;C12N9/02;C12N15/09;C12N15/62;C12N15/70;C12P21/02;C12Q1/37;G01N33/15 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
