发明名称 |
Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
摘要 |
Pre-treatment with alpha , beta unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the alpha , beta unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic. |
申请公布号 |
AU1198901(A) |
申请公布日期 |
2001.04.23 |
申请号 |
AU20010011989 |
申请日期 |
2000.10.11 |
申请人 |
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIO |
发明人 |
STEPHEN A. COSENZA;M. V. RAMANA REDDY;E. PREMKUMAR REDDY |
分类号 |
A61K45/00;A61K31/10;A61K31/12;A61K31/192;A61K31/337;A61K31/341;A61K31/35;A61K31/381;A61K31/40;A61K31/426;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/475;A61K45/06;A61P35/00;A61P43/00;C07C317/10;C07C317/14;C07C317/18;C07C317/44 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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