| 摘要 |
organic chemistry, polypeptides, pharmacy. SUBSTANCE: invention relates to polypeptide compound of the general formula (I) where R1 means lower alkanoyl group substituted with unsaturated 6-membered heteromonocyclic group containing at least one nitrogen atom that can has one or some suitable substituents; lower alkanoyl group substituted with 1,2,3,4-tetrahydroisoquinoline that can has one or some suitable substituents; lower alkanoyl group substituted with unsaturated condensed heterocyclic group containing at least one oxygen atom that can has one or some suitable substituents, or to their pharmaceutically acceptable salts. Compounds show antibacterial activity, in part, antifungal activity and activity inhibiting effect of beta-1,3-glucane synthase. Except for, invention relates to method of synthesis of indicated compounds and pharmaceutical compositions containing these compounds. Compounds can be used for prophylaxis and/or therapeutic treatment of patients with infectious diseases including infection caused by Pneumocystis carinii, for example, pneumonia caused by Pneumocystis carinii in humans or animals. EFFECT: improved method of synthesis, valuable medicinal properties. 8 cl, 2 tbl |
